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| Kauffmann,Carla; Giacomin,Ana Caroline; Arossi,Kelen; Pacheco,Leandra Andressa; Hoehne,Lucélia; Freitas,Elisete Maria de; Machado,Gérzia Maria de Carvalho; Cavalheiro,Marilene Marcuzzo do Canto; Gnoatto,Simone Cristina Baggio; Ethur,Eduardo Miranda. |
| In South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria plinioides D. Legrand, a plant species that is native in South of Brazil. The essential oil was obtained by hydro-distillation using fresh leaves of M. plinioides. The chemical composition of this essential oil (MPEO, M. plinioides essential oil) was determined by gas chromatography coupled to mass spectrometry (GC-MS). MPEO was assayed in vitro for antileishmanial properties against promastigotes of Leishmania amazonensis and Leishmania infantum, and for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antileishmanial activity; Myrciaria plinioides; Myrtaceae; Leishmania amazonensis; Leishmania infantum. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100558 |
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| Grecco,Simone S; Costa-Silva,Thais A; Sousa,Fernanda S; Cargnelutti,Stefano B; Umehara,Eric; Mendonça,Poliana S; Tempone,Andre G; Lago,Joao Henrique G. |
| Abstract Background: The therapeutic arsenal for the treatment of Leishmaniasis is limited and includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine). Given these aspects, the search for new compounds based on floristic biodiversity is crucial. In the present work, we report the isolation, characterization and antileishmanial activity of six related neolignans (1–6) of bioactive extract from Nectandra leucantha (Lauraceae) twigs. Methods: Dried and powdered twigs of N. leucantha were exhaustively extracted using n-hexane. The crude extract was dereplicated by HPLC/HRESIMS and subjected to column chromatography to yield pure compounds 1–6. Their chemical structures were identified via NMR and comparison of obtained data with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nectandra leucantha; Leishmania (L.)infantum; Antileishmanial activity; Neolignans. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100318 |
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